2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P991293
    NN-2101 99.38%
    NN-2101 is a human monoclonal antibody (mAb) targeting c-Kit/CD117. NN-2101 is used in the research of retinal disorders and diabetic macular edema.
    NN-2101
  • HY-W001094
    2-Bromo-4-fluoroanisole 452-08-4 99.69%
    2-Bromo-4-fluoroanisole is an important intermediate in organic synthesis. 2-Bromo-4-fluoroanisole can be used in the research of diabetic complications (including blindness).
    2-Bromo-4-fluoroanisole
  • HY-W007398
    5,6-Dichloronicotinic acid 41667-95-2 98.12%
    5,6-Dichloronicotinic acid is a compound produced by the reaction of 6-Hydroxynicotinic acid (HY-W001996) with chlorine. 5,6-Dichloronicotinic acid can be used as diet pills.
    5,6-Dichloronicotinic acid
  • HY-W008343
    1,3-Dimethyluracil 874-14-6 99.99%
    1,3-Dimethyluracil is a pyrimidone derives from a uracil. 1,3-Dimethyluracil found occasionally in human urine. 1,3-Dimethyluracil shows inhibition activity against hCA I and hCA II (human carbonic anhydrase) with Ki of 316.2 μM and 166.4 μM, respectively.
    1,3-Dimethyluracil
  • HY-W010248
    2-Phenylglycine 2835-06-5
    2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period.
    2-Phenylglycine
  • HY-W010649
    Isoxazole 288-14-2 99.98%
    Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor​.
    Isoxazole
  • HY-W011195
    Calcium 2-hydroxy-4-(methylthio)butanoate 4857-44-7
    Calcium 2-hydroxy-4-(methylthio)butanoate is an endogenous metabolite.
    Calcium 2-hydroxy-4-(methylthio)butanoate
  • HY-W012982
    3-Amino-2-oxazolidinone 80-65-9 ≥98.0%
    3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo. 3-Amino-2-oxazolidinone is orally active.
    3-Amino-2-oxazolidinone
  • HY-W012999
    Tiglic acid 80-59-1
    Tiglic acid is a monocarboxylic unsaturated organic acid. Tiglic acid can be isolated from croton oil. Tiglic acid agonizes FFA2 and upregulates PYY expression. Tiglic acid derivatives have anti-inflammatory activity. Tiglic acid can be used in the research of obesity, diabetes, and inflammatory diseases.
    Tiglic acid
  • HY-W013266
    N4-Acetylsulfamethoxazole 21312-10-7 99.72%
    N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is the N4-acetylated metabolite of Sulfamethoxazole (HY-B0322).
    N4-Acetylsulfamethoxazole
  • HY-W014796
    2-Naphthoxyacetic acid 120-23-0
    2-Naphthoxyacetic acid is an endogenous metabolite.
    2-Naphthoxyacetic acid
  • HY-W014983
    Neryl acetate 141-12-8 98.99%
    Neryl acetate is an essential oil component. Neryl acetate upregulates genes associated with epidermal differentiation, skin barrier formation and ceramide synthesis; it also increases filaggrin expression, total lipid and ceramide contents. Neryl acetate acts as the core driver mediating the skin barrier-forming and antibacterial effects of Helichrysum italicum essential oil.
    Neryl acetate
  • HY-W015618
    2',4'-Dimethylacetophenone 89-74-7 ≥98.0%
    2',4'-Dimethylacetophenone is an endogenous metabolite.
    2',4'-Dimethylacetophenone
  • HY-W015675
    4-Hydroxycyclohexanecarboxylic acid 17419-81-7
    4-Hydroxycyclohexanecarboxylic acid belongs to the class of organic compounds known as cyclohexanols.
    4-Hydroxycyclohexanecarboxylic acid
  • HY-W016812
    Orotic acid hydrate 50887-69-9 99.94%
    Orotic acid hydrate is an endogenous metabolite.
    Orotic acid hydrate
  • HY-W017785
    Phorone 504-20-1 ≥98.0%
    Phorone (Diisopropylidene acetone) is a glutathione (GSH) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding (Glutathione S-transferase) (Km = 0.9 mM). Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.
    Phorone
  • HY-W019877
    Sodium sulfate decahydrate 7727-73-3
    Sodium sulfate decahydrate is a ubiquitous salt that reaches toxic concentrations due to mining and other industrial activities. Sodium sulfate can be used to enhance the conjugation of phenolic drugs with sulfate and to treat hypercalcemia.
    Sodium sulfate decahydrate
  • HY-W023323
    (S)-β-Aminoisobutyric acid hydrochloride 925704-45-6 99.90%
    (S)-β-Aminoisobutyric acid hydrochloride is a cytoprotective agent, which is a non-proteinogenic amino acid enantiomer derived from valine metabolism in skeletal muscle mitochondria. The plasma level of (S)-β-Aminoisobutyric acid hydrochloride increases significantly after acute aerobic exercise (and is not affected by the AGXT2 rs37369 genotype), and it is secreted by mouse extensor digitorum longus and soleus muscles in ex vivo contraction assays. (S)-β-Aminoisobutyric acid hydrochloride specifically protects osteocytes from oxidative stress-induced cell death.
    (S)-β-Aminoisobutyric acid hydrochloride
  • HY-W027555
    Ethoxyacetic acid 627-03-2
    Ethoxyacetic acid is an endogenous metabolite.
    Ethoxyacetic acid
  • HY-W039157
    2-Acetyl-3-ethylpyrazine 32974-92-8 ≥98.0%
    2-Acetyl-3-ethylpyrazine is an endogenous metabolite.
    2-Acetyl-3-ethylpyrazine
Cat. No. Product Name / Synonyms Application Reactivity